Chao He

Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc Natl Acad Sci U S A [Full Text].

Sai Li

Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy. Science Signal [Full Text]. (Highlighted by Faculty of 1000, F1000 Microbiology).

Weiwei Wang & Lijun Wang

Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res [Full Text].

Chao He & Fudong Li

The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognitions. J Biol Chem [Full Text].

Welcome to the BioNMR Lab @ USTC

Overview

Welcome to the home page for the BioNMR Lab. Our group is located in the School of Life Sciences of the University of Science and Technology of China (USTC), and is also associated with the Hefei National Laboratory for Physical Sciences at Microscale. The group is lead by Prof. Yunyu Shi and Prof. Jihui Wu. Our group focuses on the study of biomacromolecular struture through Nuclear Magnetic Resonance (NMR) spectroscopy and X-ray crystallography in conjunction with other physical and biochemical techniques.

  • Molecular Mechanisms of Epigenetics.
  • Structural and Functional studies of key regulators in Cell Adhesion and Migration.
  • Structural Studies of Non-coding RNA.
  • Development and application of improved methods for the study of macromolecular structure.
  • Chemical biology for novel targets.

People

people

Visit Our Lab

people

Selected Publication

Wang Weiwei*, Wang Lijun*, et al. Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res. 2013 Jun 1; 41(11): 5938-48. [Full Text]

Chao He, et al.Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1879-88. [Full Text]

Sai Li*, M. P. Wandel*, et al. Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy. Science Signal. 2013 Feb 5;6(261):ra9. [Full Text]. (Highlighted by Faculty of 1000, F1000 Microbiology). Listen to the podcast interviewing Prof. Felix Randow , our collaborator in MRC LMB.

Yu Qiu, et al. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes & Dev. 2012. 26: 1376-1391. [Full Text]

Weiwei Wang, et al. Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes & Dev. 2011 Oct 1;25(19):2106-17. [Full Text]