BioNMR Lab @ USTC - Publications

Chao He

Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc Natl Acad Sci U S A [Full Text].

Sai Li

Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy. Science Signal [Full Text]. (Highlighted by Faculty of 1000, F1000 Microbiology).

Weiwei Wang & Lijun Wang

Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res [Full Text].

Chao He & Fudong Li

The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognitions. J Biol Chem [Full Text].


* 同等贡献

# 通讯作者


Yaqing Zhao, Guang Zhang, Chao He, Yide Mei, Yunyu Shi# and Fudong Li#. The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA. Cell Research (2018) 28:130-134.[Full Text].


Xiaoling Bao, Heng Liu, Xing Liu,..., Xuebiao Yao#, Jihui Wu#, Yunyu Shi#Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation J. Mol. Cell Biol. (2017) [Full Text].

Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu# and Zhiyong Zhang#. Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies. Phys. Chem. Chem. Phys. (2017) 19:21152-21164.[Full Text].

Yiyang Jiang, Fudong Li, Jihui Wu, Yunyu Shi, Qingguo Gong#Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD Plos One (2017) [Full Text].

Hongyu Bao, Na Wang, Chongyuan Wang,..., Jihui Wu#, Yunyu Shi#Structural basis for the specific recognition of 18S rRNA by APUM23 Nucleic Acids Research (2017) 45(20):12005-12014 [Full Text].

Lingna Yang, Chongyuan Wang, Fudong Li,...,Jihui Wu, Yunyu Shi, Qingguo Gong#The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3–recognition element (MRE) motif with high affinity. J. Biol. Chem. (2017) 292:16221-16234 [Full Text].

Aiai Sun, Fudong Li, Zhonghua Liu, Yiyang Jiang, Jiahai Zhang, Jihui Wu#, Yunyu Shi#Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4 Protein&Cell (2017).[Full Text].

Ling Xu, Lijun Wang, Junhui Peng,...,Jihui Wu, Yajun Tang#, Yunyu Shi# Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions. Structure (2017) 25(12):1795-1808 [Full Text].

Pengzhi Wu, Xiaodan Liu, Lingna Yang, Yitong Sun, Qingguo Gong, Jihui Wu#, Yunyu Shi# The important conformational plasticity of DsrA sRNA for adapting multiple target regulation . Nucleic Acids Research (2017) 45(16):9625-9639 [Full Text].

Mengqi Lv, Chongyuan Wang, Fudong Li, Junhui Peng, Qingguo Gong, Yunyu Shi, Yajun Tang#. Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy. Protein&Cell (2017) 8(25):25-38.[Full Text].

Li Xu*, Aimin Cheng*, Min Huang,..., Jihui Wu, Catherine C. L., Ke Ruan#. Structural insight into the recognition of acetylated histone H3K56ac mediated by the bromodomain of CREB-binding protein. The FEBS journal (2017) 284(20):3422-3436.[Full Text].

Jia Gao, E. Liang, Rongsheng Ma,..., Jihui Wu, Xuncheng Su, Wei He, Ke Ruan#Fluorine Pseudocontact Shifts Used for Characterizing the Protein–Ligand Interaction Mode in the Limit of NMR Intermediate Exchange Angew. Chemie Int. Ed. (2017) 129(42):13162-13166 [Full Text].

J Liu, F Li, H Bao, Y Jiang, S Zhang, R Ma, J Gao, J Wu, K Ruan#. The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water‐mediated interaction network. The FEBS journal (2017) 284(7):1082-1095.[Full Text].

J Liu, J Gao, F Li, R Ma, Q Wei, A Wang, J Wu, K Ruan#. NMR characterization of weak interactions between RhoGDI2 and fragment screening hits. BBA-General Subjects (2017) 1861(1):3061-3070.[Full Text].


Qingtao Wei, Jiajing Chen, Juan Mi, Jiahai Zhang, Ke Ruan# and Jihui Wu#. NMR Backbone Assignment of Large Proteins by Using (13) Cα -Only Triple-Resonance Experiments. Chemistry-A European Journal (2016) 22(28):9556-9564.[Full Text].

Na Wang, Fudong Li, Hongyu Bao, Jie Li, Jihui Wu# and Ke Ruan#. NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains. ChemBioChem (2016) 17(15):1456-1463.[Full Text].

Rongsheng Ma, Pengchao Wang, Jihui Wu and Ke Ruan#. Process of Fragment-Based Lead Discovery—A Perspective from NMR. Molecules (2016) 21:854.[Full Text].

Rongsheng Ma, Q.F.Li, Aidong Wang, Jiahai Zhang, Zhijun Liu,Jihui Wu Xuncheng Su# and Ke Ruan#. Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer. Phys. Chem. Chem. Phys. (2016) 18:13794-13798.[Full Text].

Hongyu Bao, Fudong Li, Chongyuan Wang, Na Wang, Yiyang Jiang, Yajun Tang, Jihui Wu#, and Yunyu Shi#. Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3. J. Biol. Chem. (2016) 291(32):16709-16719.[Full Text].

Junhui Peng, and Zhiyong Zhang#. Unraveling low-resolution structural data of large biomolecules by constructing atomic models with experiment-targeted parallel cascade selection simulations. Sci. Rep. (2016) 6:29360.[Full Text].

Jun Dong*, Yonghui Zhang*, Zhiyong Zhang#. pH dependence of ligand-induced human epidermal growth factor receptor activation investigated by molecular dynamics simulations. Journal of Molecular Modeling. (2016) 22(6):1-12.[Full Text].

Yun Bao, Zhonghua Liu, Jiahai Zhang, Jihui Wu#, and Yunyu Shi#. 1H, 13C and 15N resonance assignments and secondary structure of the human PHF6-ePHD1 domain. Biomolecular NMR Assignment. (2016) 10(1):1-4.[Full Text].

Chongyuan Wang, Yuwei Zhu, Hongyu Bao, Yiyang Jiang, Chao Xu, Jihui Wu#, and Yunyu Shi#. A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1. Nucleic Acids Research (2016) 44(2):968-982.[Full Text].


Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong and Zhiyong Zhang#. Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations. Protein&Cell (2015) 6(8):619-623.[Full Text].

Lijun Wang, Weiwei Wang, Fudong Li, Jiahai Zhang, Jihui Wu, Qingguo Gong# and Yunyu Shi#. Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq. Nucleic Acids Research (2015) 43(4):2400-2411.

Zhonghua Liu, Fudong Li, Beibei Zhang, Sai Li, Jihui Wu# and Yunyu Shi#. Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. Journal of Biological Chemistry (2015) 290:6630-6638.


Fudong Li*, Debiao Zhao*, Jihui Wu# and Yunyu Shi#. Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition. Cell Research (2014) 24(12):1490-1492.

Juncheng Wang, Su Qin, Fudong Li, Sai Li, Wei Zhang, Junhui Peng, Zhiyong Zhang, Qingguo Gong, Jihui Wu#, Yunyu Shi#. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding. Cell Research (2014) 24:890–893.

Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang#.Characterization of Protein Flexibility Using Small-Angle X-Ray Scattering and Amplified Collective Motion SimulationsBiophysical Journal(2014)4(19):956-964.[Full Text].

Zhenhua Shao*, Wei Yan*, Junhui Peng, Xiaobing Zuo, Yang Zou, Fudong Li, Deshun Gong, Rongsheng Ma, Jihui Wu, Yunyu Shi, Zhiyong Zhang, Maikun Teng,Xu Li#, and Qingguo Gong#. Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Research 2014, Vol. 42, No. 1 509-525>.

Jia Gao,Rongsheng Ma,Wei Wang,Na Wang,Ryan Sasaki,David Snyderman,Jihui Wu,Ke Ruan. Automated NMR Fragment Based Screening Identified a Novel Interface Blocker to the LARG/RhoA Complex. PLOS ONE (2014)9(2): e88098.

Chongyuan Wang, Yuwei Zhu, Tamar B Caceres, Lei Liu, Junhui Peng, Junchen Wang, Jiajing Chen, Xuwen Chen, Zhiyong Zhang, Xiaobing Zuo, Qingguo Gong, Maikun Teng, Joan M Hevel, Jihui Wu#and Yunyu Shi#. Structural Determinants for the Strict Monomethylation Activity by Trypanosoma bruceiProtein Arginine Methyltransferase 7. Structure. 2014 May 6; 22(5): 756-768

Chongyuan Wang*,Yuwei Zhu*,Jiajia Chen,XuLi,Junhui Peng,Jiajing Chen,Yang Zou,Zhiyong Zhang,Hong Jin,Pengyuan Yang,Jihui Wu,Liwen Niu,Qingguo Gong,Maikun Teng#,Yunyu Shi#.Crystal structure of arginine methyltransferase 6 from Trypanosoma brucei PLoS One 2014 Feb 3; 9(2): e87267

Zhonghua Liu, Fudong Li, Ke Ruan, Jiahai Zhang, Yide Mei, Jihui Wu# and Yunyu Shi#. Structural and Functional Insights into the Human Borjeson-Forssman-Lehmann Syndrome-associated Protein PHF6. J Biol Chem, 2014, April 4; 289(14):10069-83


Wang Weiwei*, Wang Lijun*, Wu Jihui, Gong Qingguo#, Shi Yunyu#. Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res. 2013 Jun 1; 41(11): 5938-48.

Chao He, Sreerekha S. Pillai*, Francesca Taglini*, Fudong Li, Ke Ruan, Jiahai Zhang, Jihui Wu, Yunyu Shi#, ElizabethH. Bayneb#. Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1879-88.

Chao He*, Fudong Li*, Jiahai Zhang, Jihui Wu#, and Yunyu Shi#. The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition. J Biol Chem. 2013 Feb 15;288(7):4692-703.

Deshun Gong, Fan Yang, Fudong Li, Dandan Qian, Minhao Wu, Zhenhua Shao, Mian Wu, Jihui Wu#, Yunyu Shi#. Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region. Biochem J. 2013 February 15; 450(Pt 1): 85–94.

Sai Li*, M. P. Wandel*, Fudong Li, Zhonghua Liu, Chao He, Jihui Wu, Yunyu Shi#, F. Randow#. Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy. Science Signal. 2013 Feb 5;6(261):ra9.


Yu Qiu, Lei Liu, Chen Zhao, Chuanchun Han, Fudong Li, Jiahai Zhang, Yan Wang, Guohong Li, Yide Mei, Mian Wu, Jihui Wu#, Yunyu Shi#. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes & Dev. 2012. 26: 1376-1391.

Zhenwei Song, Peiwen Wu, Peng Ji, Jiahai Zhang, Qingguo Gong, Jihui Wu#, Yunyu Shi#. Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets. Biochemistry. 2012 Aug 21;51(33):6667-78.

Bo Wu, Fengsong Wang, Jiahai Zhang, Zhiyong Zhang, Liying Qin, Junhui Peng, Fudong Li, Jianping Liu, Guowei Lu, Qingguo Gong, Xuebiao Yao, Jihui Wu#, Yunyu Shi#. Identification and structural basis for a novel interaction between Vav2 and Arap3. J Struct Biol. 2012 Oct;180(1):84-95.

Lei Liu, Su Qin,Jiahai Zhang,Peng Ji,Yunyu Shi#,Jihui Wu#. (2012) Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA. J Struct Biol. 2012 Oct;180(1):165-73.

Jie Wen, Pei Zhou#, Jihui Wu#. Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl–methyl NOESY for large proteins. J Magn Reson. 2012 May;218:128-32.

Xinxin Li, Kaixian Liu, Fudong Li, Juncheng Wang, Hongda Huang, Jihui Wu#,Yunyu Shi#. Structure of the C-terminal tandem BRCT repeats of Rtt107 reveals a critical role in the interaction with γH2A during DNA damage repair. J Biol Chem. 2012 Mar 16;287(12):9137-46.

Yu Qiu, Wen Zhang, Chen Zhao, Yan Wang, Weiwei Wang, Jiahai Zhang, Zhiyong Zhang, Guohong Li, Yunyu Shi, Xiaoming Tu#, Jihui Wu#. Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA. Biochem J. 2012 Mar 15;442(3):527-38.

Zhenhua Shao, Fudong Li, Shirley M.-H. Sy, Wei Yan, Zhiyong Zhang, Deshun Gong, Bin Wen, Michael S.Y. Huen, Qingguo Gong, Jihui Wu#, Yunyu Shi#. Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure. J Struct Biol. 2012 Feb;177(2):459-68.


Weiwei Wang, Lijun Wang, Yang Zou, Jiahai Zhang, Qingguo Gong, Jihui Wu#, Yunyu Shi# (2011) Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes & Development. 25(19):2106-2117.

Hu H, Liu Y, Wang M, Fang J, Huang H, Yang N, Li Y, Wang J, Yao X, Shi Y, Li G, Xu R# (2011) Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Genes Dev. 25(9):901-906.

Su Qin, Lei Jin, Jiahai Zhang, Lei Liu, Peng Ji, Mian Wu, Jihui Wu and Yunyu Shi. (2011) Recognition of unmodified histone H3 by the first PHD finger of Bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases MOZ and MORF. Journal of Biological Chemistry. 286(42):36944-36955

Jianping Liu, Jiahai Zhang, Qingguo Gong, Peng Xiong, Hongda Huang, Bo Wu, Guowei Lu, Jihui Wu and Yunyu Shi. (2011) Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain. Journal of Biological Chemistry, 286(33):29218-29226

Jie Wen, Jihui Wu, and Pei Zhou. (2011) Sparsely sampled high-resolution 4-D experiments for efficient backbone resonance assignment of disordered proteins. Journal of Magnetic Resonance, 209(1): 94-100

Fangming Wu, Yiwei Liu, Zhiqiang Zhu, Hongda Huang, Bo Ding, Jihui Wu, and Yunyu Shi (2011) The 1.9 ? crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones. Journal of Structural Biology, 174(1):213-222

Peng Ji, Guang Yang, Jiahai Zhang, Jiawen Wu, Zhengjun Chen, Qingguo Gong, Jihui Wu, Yunyu Shi. (2011) Solution structure of the second PDZ domain of zonula occludens 1. Proteins: Structure, Function, and Bioinformatics ,79(4):1342-1346


Bin Rui, Tie Shen, Hong Zhou, Jianping Liu, Jiusheng Chen, Xiaosong Pan, Haiyan Liu, Jihui Wu, Haoran Zheng and Yunyu Shi. (2010) A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress. BMC Systems Biology, 4: 122.

Yiwei Liu*, Hongda Huang*, Bo O. Zhou, Shan-Shan Wang, Yingxia Hu, Xu Li, Jianping Liu, Jianye Zang, Liwen Niu, Jihui Wu, Jin-Qiu Zhou, Maikun Teng#, and Yunyu Shi#. (2010) Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing. Journal of Biological Chemistry, 285(6):4251-62.

Xingsheng Wang, Shaojie Zhang, Jiahai Zhang, Xiaojuan Huang, Chao Xu, Weiwei Wang, Zhijun Liu, Jihui Wu, and Yunyu Shi. (2010) A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR. Journal of Biological Chemistry, 285(7):4951-63.


Xiaojuan Huang, Monique Beullens, Jiahai Zhang, Yi Zhou, Emilia Nicolaescu, Bart Lesage, Qi Hu, Jihui Wu, Mathieu Bollen, and Yunyu Shi. (2009) Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21. Journal of Biological Chemistry, 284(37):25375-87.

Jingjun Hong , Jiahai Zhang , Zhijun Liu , Su Qin , Jihui Wu and Yunyu Shi. (2009) Solution Structure of S. cerevisiae PDCD5like protein and its promoting role in H2O2-induced apoptosis in yeast. Biochemistry, 48(29):6824-34.

Zhijun Liu, Jiahai Zhang, Xingsheng Wang, Yanwei Ding, Jihui Wu and Yunyu Shi. (2009) Temperature-induced partially unfolded state of hUBF HMG Box-5: Conformational and dynamic investigations of the Box-5 thermal intermediate ensemble. Proteins: Structure, Function, and Bioinformatics, 77(2):432-47.

Tie Shen, Weiqun Shen, Ying Xiong, Haiyan Liu, Haoran Zheng, Hong Zhou, Bin Rui, Jianping Liu, Jihui Wu, Yunyu Shi. (2009) Increasing the accuracy of mass isotopomer analysis through calibration curves constructed using biologically synthesized compounds. Journal of Mass Spectrometry, 44(7):1066-80.


Ying Liu, Xiqing Wang, Jiahai Zhang, Hongda Huang, Bo Ding, Jihui Wu, and Yunyu Shi. (2008) Structural Basis and Binding Properties of the Second Bromodomain of Brd4 with Acetylated Histone Tails. Biochemistry, 47 (24): 6403–6417

Jiangxin Liu, Jiahai Zhang, Yinshan Yang, Hongda Huang, Weiqun Shen, Qi Hu, Xingsheng Wang, Jihui Wu, and Yunyu Shi. (2008) Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor. Protein Science, 17:1003-1014.

Fangming Wu, Jiahai Zhang, Jianping Sun, Hongda Huang, Peng Ji, Wangsheng Chu, Meijuan Yu, Feifei Yang, Ziyu Wu, Jihui Wu and Yunyu Shi. (2008) Solution structure of human DESR1, a CSL zinc-binding protein. Proteins: Structure, Function, and Bioinformatics, 71(1) 514-518.


Xiaogang Niu, Quan Chen, Jiahai Zhang, Weiqun Shen, Yunyu Shi, and Jihui Wu. (2007) Interesting Structural and Dynamical Behaviors Exhibited by the AF-6 PDZ Domain upon Bcr Peptide Binding. Biochemistry, 46 (51):15042 -15053

Qi Hu, Weiqun Shen, Hongda Huang, Jiangxin Liu, Jiahai Zhang, Xiaojuan Huang, Jihui Wu, and Yunyu Shi. (2007) Insight into the Binding Properties of MEKK3 PB1 to MEK5 PB1 from Its Solution Structure. Biochemistry 46(47):13478-89.

Hongda Huang , Jiahai Zhang , Weiqun Shen , Xingsheng Wang , Jiawen Wu , Jihui Wu and Yunyu Shi. (2007) Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails. BMC Structural Biology, 7:57.

Zhe Shi, Sartaj Tabassum, Wei Jiang, Jiahai Zhang, Suvigya Mathur, Jihui Wu and Yunyu Shi.(2007) Identification of a Potent Inhibitor of Human Dual-Specific Phosphatase, VHR, from Computer-Aided and NMR-Based Screening to Cellular Effects. ChemBioChem, 8(17):2092-2099.

Jiawen Wu, Yinshan Yang, Jiahai Zhang, Peng Ji, Wenjing Du, Peng Jiang, Dinghai Xie, Hongda Huang, Mian Wu, Guangzhao Zhang, Jihui Wu and Yunyu Shi. (2007) Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins. Journal of Biological Chemistry, 282(49):35988-35999.

Xianju Jin, Jiahai Zhang, Haiming Dai, Hongbin Sun, Dandan Wang, Jihui Wu and Yunyu Shi.(2007) Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. Biophysical Chemistry, 129, 269-278.

Quan Chen, Xiaogang Niu, Yingqi Xu, Jihui Wu, and Yunyu Shi. (2007) Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex. Protein Science, 16, 1053-1062.

Hongbin Sun, Jiangxin Liu, Jiahai Zhang, Weiqun Shen, Hongda Huang, Chao Xu, Haiming Dai, Jihui Wu and Yunyu Shi. (2007) Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4. Biochemical and Biophysical Research Communications 358, 435-441.

Jiahai Zhang, Xiang Li, Bo Yao, Weiqun Shen, Hongbin Sun, Chao Xu, Jihui Wu and Yunyu Shi. (2007) Solution structure of the first SH3 domain of human vinexin and its interaction with vinculin peptides. Biochemical and Biophysical Research Communications 357, 931-937.

Weiqun Shen, Chao Xu, Wei Huang, Jiahai Zhang, Justin E. Carlson, Xiaoming Tu, Jihui Wu, and Yunyu Shi.(2007) Solution Structure of Human Brg1 Bromodomain and Its Specific Binding to Acetylated Histone Tails. Biochemistry 46, 2100-2110.

Dandan Wang, Jiahai Zhang, Xianju Jin, Jihui Wu, and Yunyu Shi. (2007) Investigation of the Structural Stability of hUBF HMG Box 5 by Native-State Hydrogen Exchange. Biochemistry 46,1293 -1302.

Bo Yao, Jiahai Zhang, Haiming Dai, Jianping Sun, Yuanyuan Jiao, Yajun Tang, Jihui Wu and Yunyu Shi. (2007) Solution structure of the second SH3 domain of human CMS and a newly identified binding site at the C-terminus of c-Cbl. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1774, 35-43.


Haiming Dai, Wei Huang, Jian Xu, Bo Yao, Shangmin Xiong, Husheng Ding, Yajun Tang, Haiyan Liu, Jihui Wu and Yunyu Shi. (2006) Binding model of human coactosin-like protein with filament actin revealed by mutagenesis. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1764, 1688-700.

Sun, H. B., Dai, H. M., Zhang, J. H., Jin, X. J., Xiong, S. M., Xu, J., Wu, J. H. and Shi, Y. Y. (2006) Solution structure of calponin homology domain of Human MICAL-1. Journal of Biomolecular Nmr 36, 295-300.

Li, X., Zhang, J. H., Cao, Z. X., Wu, J. H. and Shi, Y. Y. (2006) Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin. Protein Science 15, 2149-2158.

Xu, J. J., Zhang, J. H., Wang, L., Zhou, J., Huang, H. D., Wu, J. H., Zhong, Y., and Shi, Y. Y. (2006) Solution structure of Urm1 and its implications for the origin of protein modifiers. Proceedings of the National Academy of Sciences of the United States of America 103, 11625-11630.

Man, N., Cheng, Y. Y., Xu, T. W., Ding, Y., Wang, X. M., Li, Z. W., Chen, Z. C., Huang, G. Y., Shi, Y. Y., and Longping, W. (2006) Dendrimers as potential drug carriers. Part II. Prolonged delivery of ketoprofen by in vitro and in vivo studies. European Journal of Medicinal Chemistry 41, 670-674.

Xu, C., Zhang, J. H., Huang, X. J., Sun, J. P., Xu, Y. Q., Tang, Y. J., Wu, J. H., Shi, Y. Y., Huang, Q. H., and Zhang, Q. H. (2006) Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. Journal of Biological Chemistry 281, 15900-15908.


Zhang, X. C., Zhang, J. H., Li, X., Xu, J. J., Huang, H. D., Chen, Q., Wu, J. H., and Shi, Y. Y. (2005) Compact molten globule-like state of hUBF HMG Box1 at extremely low pH. Biochimica Et Biophysica Acta-Proteins and Proteomics 1748, 66-73.

Ding, H. S., Yang, Y. D., Zhang, J. H., Wu, J. H., Liu, H. Y., and Shi, Y. Y. (2005) Structural basis for SUMO-E2 interaction revealed by a complex model using docking approach in combination with NMR data. Proteins-Structure Function and Bioinformatics 61, 1050-1058.

Sun, J. P., Zhang, J. H., Wu, F. M., Xu, C., Li, S. J., Zhao, W., Wu, Z. Y., Wu, J. H., Zhou, C. Z., and Shi, Y. Y. (2005) Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module. Biochemistry 44, 8801-8809.

Zhang, X. C., Xu, Y. Q., Zhang, J. H., Wu, J. H., and Shi, Y. Y. (2005) Structural and dynamic characterization of the acid-unfolded state of hUBF HMG box 1 provides clues for the early events in protein folding. Biochemistry 44, 8117-8125.

Xu, C., Zheng, P. Z., Shen, S. H., Xu, Y. Q., Wei, L., Gao, H. J., Wang, S. N., Zhu, C. R., Tang, Y. J., Wu, J. H., Zhang, Q. H., and Shi, Y. Y. (2005) NMR structure and regulated expression in APL cell of human SH3BGRL3. Febs Letters 579, 2788-2794.

Zhou, H. Y., Xu, Y. Q., Yang, Y. D., Huang, A. D., Wu, J. H., and Shi, Y. Y. (2005) Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from neurexin and Bcr. Journal of Biological Chemistry 280, 13841-13847.

Xu, C., Xu, Y. Q., Tang, Y. J., Wu, J. H., Shi, Y. Y., Huang, Q. H., and Zhang, Q. H. (2005) Letter to the Editor: Backbone and side chain assignments of human peptidylprolyl isomerase like 1 (hPPIL1). Journal of Biomolecular Nmr 31, 179-180.

Ding, H. S., Xu, Y. Q., Chen, Q., Dai, H. M., Tang, Y. J., Wu, J. H., and Shi, Y. Y. (2005) Solution structure of human SUMO-3 C47S and its binding surface for Ubc9. Biochemistry 44, 2790-2799.

Wang, C. G., Cai, Z., Lu, W. Y., Wu, J. H., Xu, Y. Q., Shi, Y. Y., and Chi, C. W. (2005) A novel short-chain peptide BmKX from the chinese scorpion Buthus martensi karsch, sequencing, gene cloning and structure determination. Toxicon 45, 309-319.

Dai, H. M., Wu, J. H., Xu, Y. Q., Tang, Y. J., Ding, H. S., and Shi, Y. Y. (2004) Letter to the Editor: H-1, C-13 and N-15 resonance assignments and the secondary structures of human Coactosin like protein (hCLP) D123N. Journal of Biomolecular Nmr 29, 455-456.

Cai, Z., Xu, C. Q., Xu, Y. Q., Lu, W. Y., Chi, C. W., Shi, Y. Y., and Wu, J. H. (2004) Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch. Biochemistry 43, 3764-3771.

Xiao, Y. Z., Chen, Q., Hang, J., Shi, Y. Y., Xiao, Y. Z., Wu, J., Hong, Y. Z., and Wang, Y. P. (2004) Selective induction, purification and characterization of a laccase isozyme from the basidiomycete Trametes sp AH28-2. Mycologia 96, 26-35.

Zhang, J. H., Du, D. Z., and Wu, J. H. (2003) Identification for the hydrogen and carbon spectra of cilnidipine by nuclear magnetic resonance. Chinese Journal of Analytical Chemistry 31, 1044-1047.

Zhu, J., Zhu, Q. Q., Shi, Y. Y., and Liu, H. Y. (2003) How well can we predict native contacts in proteins based on decoy structures and their energies? Proteins-Structure Function and Genetics 52, 598-608.

Zeng, W. Y., Wang, Y. H., Zhang, Y. C., Yang, W. L., and Shi, Y. Y. (2003) Functional significance of conserved glycine 127 in a human dual-specificity protein tyrosine phosphatase. Biochemistry-Moscow 68, 634-638.

Wang, J. H., Zhang, Z. Y., Liu, H. Y., and Shi, Y. Y. (2003) Quasiequilibrium unfolding thermodynamics of a small protein studied by molecular dynamics simulation with an explicit water model. Physical Review E 67.

Xiao, Y. Z., Tu, X. M., Wang, J., Zhang, M., Cheng, Q., Zeng, W. Y., and Shi, Y. Y. (2003) Purification, molecular characterization and reactivity with aromatic compounds of a laccase from basidiomycete Trametes sp strain AH28-2. Applied Microbiology and Biotechnology 60, 700-707.

Wang, Y. H., Zeng, W. Y., and Shi, Y. Y. (2003) Mutation of arginines near the active site Cys(124) of human dual-specificity phosphatase and its effect on the enzymatic activity. Acta Biochimica Et Biophysica Sinica 35, 149-153.

Yang, W. L., Xu, Y. Q., Wu, J. H., Zeng, W. Y., and Shi, Y. Y. (2003) Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor. Biochemistry 42, 1930-1938.


Xu, Y. Q., Yang, W. L. Wu, J. H. and Shi, Y. Y. (2002) Solution Structure of the First HMG Box Domain in Human Upstream Binding Factor. Biochemistry 41, 5415-5420.

Tu, X. M., Wu, J. H., Xu, Y. Q., and Shi, Y. Y. (2001) H-1, C-13 and N-15 resonance assignments and secondary structure of ADR6 DNA-binding domain. Journal of Biomolecular Nmr 21, 187-188.

Liu, S. S., Yin, C. S., Shi, Y. Y., Cai, S. X., and Li, Z. L. (2001) MEDV-13 for QSAR studies on the COX-2 inhibition by indomethacin amides and esters. Chinese Journal of Chemistry 19, 751-756.

Han, J. G., and Shi, Y. Y. (2001) A computational study on geometries, electronic structures and ionization potentials of MSi15 (M = Cr, Mo, W) clusters by density functional method . Chemical Physics 266, 33-40.

Zhang, Z. Y., Zhu, Y. J., and Shi, Y. Y. (2001) Molecular dynamics simulations of urea and thermal-induced denaturation of S-peptide analogue. Biophysical Chemistry 89, 145-162.

Zeng, W. Y., Zhang, X. C., Tu, X. M., Guang, S. H., Xiao, Y. Z., and Shi, Y. Y. (2001) Expression and purification of the DNA-binding domain of the human transcription factor E2F1. Protein Expression and Purification 21, 99-104.