Chao He

Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc Natl Acad Sci U S A [Full Text].

Sai Li

Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy. Science Signal [Full Text]. (Highlighted by Faculty of 1000, F1000 Microbiology).

Weiwei Wang & Lijun Wang

Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res [Full Text].

Chao He & Fudong Li

The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognitions. J Biol Chem [Full Text].

中国科学技术大学-生物大分子核磁共振波谱实验室

研究方向

中国科学技术大学生物大分子核磁共振波谱实验室隶属于中国科学技术大学生命科学学院和合肥微尺度物质科学国家实验室。实验室负责人为中国科学院院士施蕴渝教授和吴季辉教授。现有正教授三名,副教授二名。主要研究方向为应用核磁共振波谱学(NMR),X-射线晶体学(X-Ray)和冷冻电镜(Cryo-EM)研究生命过程中重要的生物大分子结构与功能。

  • 表观遗传重要蛋白质和复合物的结构生物学研究
  • 细胞粘附和迁移相关蛋白质的结构和分子机理研究
  • 非编码RNA的结构生物学研究
  • 生物大分子核磁共振方法研究
  • 基于片段的化学生物学研究

成员

people

实验室

people

代表性论文

Wang Weiwei*, Wang Lijun*, et al. Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res. 2013 Jun 1; 41(11): 5938-48. [Full Text]

Chao He, et al.Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1879-88. [Full Text]

Sai Li*, M. P. Wandel*, et al. Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy. Science Signal. 2013 Feb 5;6(261):ra9. [Full Text]. (Highlighted by Faculty of 1000, F1000 Microbiology). Listen to the podcast interviewing Prof. Felix Randow , our collaborator in MRC LMB.

Yu Qiu, et al. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes & Dev. 2012. 26: 1376-1391. [Full Text]

Weiwei Wang, et al. Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes & Dev. 2011 Oct 1;25(19):2106-17. [Full Text]